With the APIs, you can automate many administrative tasks. Some examples include:
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Perform a configuration run to apply changes to Management Console settings. For more information, see REST API endpoints for managing GitHub Enterprise Server. 
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Configure LDAP sync. For more information, see REST API endpoints for LDAP. 
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Collect statistics about your enterprise. For more information, see REST API endpoints for admin stats. 
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Manage your enterprise account. For more information, see Managing enterprise accounts. 
For the complete documentation for the GitHub Enterprise Server APIs, see GitHub REST API and GitHub GraphQL API.